Reverend Lemuel G. Walden was born in 1833 in Virginia. He served as the fourth pastor of Twelfth Baptist Church in Boston, Massachusetts, from 1880 to 1885. 

During his tenure, he led a congregation of approximately 650 parishioners, continuing the church's mission of providing spiritual guidance and support to the African-American community in Boston.

After resigning from Twelfth Baptist Church in 1885, Rev. Walden's subsequent endeavors are not well-documented. He passed away in 1926 and is interred at Mount Hope Cemetery in Mattapan, Suffolk County, Massachusetts.

TBC operated with a host of visiting ministers for nearly a year after Reverend Walden’s resignation until Reverend Robert N. Fairfax was ordained as the fifth pastor in 1886.